Dec 1, 2005 · John V. Hinshaw Although these ionization detectors share several features, their implementations differ significantly. Detector performance characteristics (sensitivity, minimum detectable quantity, linearity, and selectivity) are affected strongly by the type of ionization mechanism, the internal electrode arrangement, and the electronics.

Nov 13, 2024 · The 54th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2025) will be held from Sunday through Thursday, June 15-19, 2025, in Bruges, Belgium.

Jul 1, 2013 · where gradient time (t G) is in minutes, S is a shape factor and a value of 4 is typically used where the accurate value is not known, k* is the average retention factor for which a value of 5 is typically optimal, ΔΦ is the change in organic composition from the scouting gradient, V m is the column volume (see equation 2) in milliliters, and F …

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Nov 1, 2019 · where â s is the spacing between the apex of two signals with respect to their average baseline width, w av = (w 1 +w 2)/2.This equation is applicable to all signal shapes; however, the significance of the calculated value depends …

Aug 1, 2018 · Douglas E. Raynie "Sample Prep Perspectives" editor Douglas E. Raynie is a Department Head and Associate Professor at South Dakota State University. His research interests include green chemistry, alternative solvents, sample preparation, high-resolution chromatography, and bioprocessing in supercritical fluids.

Jun 10, 2024 · Case Studies from an Early-Phase Small-Molecule Development Project: Background Information. A case study from my experience as a chemistry, manufacturing, and controls (CMC) analytical team lead supporting an early-phase small-molecule oncology drug development project was used to illustrate how CoAs expedite quality documentation of testing methods and results.

Jan 1, 2017 · Figure 1: Simulated chromatograms for a mixture of six neutral compounds (unlabeled peaks between approximately 3 and 9 min) and two carboxylic acids at (a) pH 7.0 and (b) pH 3.0. The peak at approximately 0.75 min is t 0.. When ionizable analytes are present, dramatic changes in retention can take place when the mobile-phase pH is altered.

Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.