A man remains hospitalized Friday after being shot by police after allegedly stealing a garbage truck and leading police on a ...

A $200,000 lottery win has left an Upstate, South Carolina man wanting more. The man won the cash off a $5 scratch-off ticket ...

President Donald Trump signed a pair of executive orders late Thursday, shaking up his trade policy just hours before tariffs ...

Trump has heckled Canada for months and suggested it should become its 51st U.S. state. He had threatened to impose the ...

A woman in Los Angeles County was left with a nearly $8,000 parking bill after visiting a California hospital, KCAL reported.

A record share of U.S. kindergartners had an exemption for a required vaccination last school year, and coverage for all ...

The National Transportation Safety Board will wrap up its public testimony on Friday about the fatal midair crash between an ...

Lantern flies, an invasive species that has caused havoc across the United States, are now in the Upstate area of South Carolina. "This one moves a lot, breeds a lot, makes a lot of babies, eats a lot ...

Experts warn against the risks of diphenhydramine, suggesting safer alternatives for allergy relief with fewer side effects ...

An inmate in Lancaster, South Carolina, has been charged with the murder of another inmate, the South Carolina Department of Corrections (SCDC) says.

Each week on WYFF News 4, we will introduce you to new businesses, activities, restaurants, events, etc. in the Upstate area of South Carolina.

Roger Goodell also gave a health update on the league employee who was seriously injured in the gun attack that killed four people at the Midtown Manhattan building that houses the NFL's offices.