Sustained benefits seen in overall survival, progression-free survival, objective response rate with combo vs sunitinib.

Significant increase seen in crude nitrous oxide poisoning rate from 2010 to 2018, but no increase seen from 2019 to 2023.

HealthDay News — Electronic cigarette (e-cigarette) flavor restriction policies are associated with reductions in e-cigarette use, according to a study published online July 30 in JAMA Network Open.

The randomized, double-blind, CONVOKE trial evaluated the safety and efficacy of CT-155, a PDT that provides interactive psychosocial intervention techniques via a smartphone app.

Findings from key secondary endpoints showed 59.6% of patients taking orforglipron 36mg (highest dose) achieved a reduction in body weight of 10% or greater vs 8.6% of patients receiving placebo; ...

As part of a postmarketing requirement, Valneva will be initiating a study to assess the risk of severe chikungunya-like adverse reactions following administration of Ixchiq.

No significant increases seen in rate of hospital contacts for any of 29 adverse events in 28-day risk period after vaccination.

The sBLA for the pediatric indication is supported by data from the randomized, double-blind, placebo-controlled, phase 3 SPACE trial.

Notable Drug Approvals.

HealthDay News — Having a supratherapeutic international normalized ratio (INR) while taking warfarin does not significantly increase the risk for brain bleeding after blunt head trauma in older ...

Stronger differential effect for CPAP seen for those without excessive sleepiness, without increased blood pressure.

HealthDay News — Canagliflozin is associated with a clinically meaningful reduction in hemoglobin A1c (HbA1c) for children and adolescents with type 2 diabetes mellitus (T2DM), according to a study ...