Researchers uncover how cells internalize transplanted mitochondria, paving the way for new energy-restoring therapies for Parkinson’s and Alzheimer’s.

This valuable study proposes a theoretical model of clathrin coat formation based on membrane elasticity that seeks to determine whether this process occurs by increasing the area of a protein-coated ...

Clathrin-mediated endocytosis (CME) is a significant route of internalization for macromolecules and membrane receptors in eukaryotic cells such as vascular endothelial growth factor (VEGF), ...

Proteome-scale visual screening in budding yeast provides a functional catalog of plasma membrane repair proteins and reveals the coordinated cellular responses at the bud tip and the damage site.

This study is reported by Hualan Chen’s group from the State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences.

GAK and its chaperone protein, Hsc70, are known to be recruited to clathrin-coated vesicles (CCVs) to mediate clathrin uncoating. Previous studies have proposed that early recruitment of GAK–Hsc70 to ...

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Beijing Key Laboratory of Cardiovascular Receptors Research; Key Laboratory of Cardiovascular Molecular ...

Endocytosis is the process by which cells take in molecules from their surroundings. Clathrin-dependent endocytosis requires the recruitment of clathrin to help curve the plasma membrane into the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 11 (May 23, 2000), pp. 6120-6125 (6 pages) The GTPase dynamin I is required for synaptic vesicle (SV) ...

Cells have a clever way called clathrin-mediated endocytosis to transport cargos like growth factors across the cell membrane and into the cell. Researchers used a sophisticated fluorescence ...