Vikings vs. 49ers: Game Preview and Prediction Playoff football has officially commenced for the San Francisco 49ers as they renew their “Quest for Six” campaign.

BetMGM NFL odds: 49ers by 5½. Series record: 49ers lead 25-24-1. Against the spread: 49ers 1-0, Vikings 1-0. Last meeting: Vikings beat the 49ers 22-17 in Minnesota on Oct. 23, 2023.

The Vikings' defense had a very strong game against the hapless Giants, but the 49ers, with a plethora of weapons and the best playcaller in the league, are a completely different story.

In a game between two evenly matched quarterbacks and two good defenses, I'll take the Vikings to keep things close against the 49ers." -- Sean Wagner-McGough on why he's taking the Vikings to cover ...

5 key players to watch in 49ers-Vikings Week 7 game QB Brock Purdy, 49ers: Purdy had the worst game of his young career vs. a historically stout Cleveland D.

Week 2, Vikings vs. 49ers: Why intermediate passing game, blitz pickup will determine which team gets to 2-0 These matchups will play a critical role in deciding which team improves to 2-0 in Week 2 ...

Vikings vs 49ers game info • Location: Levi's Stadium, Santa Clara, CA • Date: Sunday, November 28, 2021 • Time: 4:25 p.m. ET • TV: FOX Vikings at 49ers betting preview Weather ...

49ers Deebo Samuel makes a catch during the first half against the Vikings during the NFC Divisional Round Playoff game at Levi's Stadium Jan. 11, 2020. (Thearon W. Henderson/Getty Images) ...

The Vikings, who played a tough game last week, had one possession in the quarter and never got a first down. The 49ers, meanwhile, added 10 more points, and then another field goal to open the ...