The Buffalo Bills are 4-1, but it's clear they have deficiencies on both sides of the ball. Their receivers can't separate, and their defense lacks any sort of star power off the edge and need help in the secondary.

Here is everything you need to know about the Bills' schedule for the 2025 season, including TV and streaming options for each game.

The New England Patriots, behind young quarterback Drake Maye, handed the Buffalo Bills their first loss of the season on 'Sunday Night Football.'

Bills head coach Sean McDermott gave some updates during his Monday afternoon press conference following the game. The most notable of which was regarding one of Buffalo's best but also most oft-injured forces in the linebackers group, Matt Milano, whose return to the field only lasted one half.

Getting Josh Allen a new weapon to work with is never a bad idea, especially if the Bills end up winning the Super Bowl. Williams has dealt with a hamstring injury throughout the first month of the season for the Tigers, but he appears to be healthy after playing this past weekend against the North Carolina Tar Heels.

Josh Allen and the Buffalo Bills were reminded of what they were missing on offense when watching Stefon Diggs spark the New England Patriots' win on Sunday night.

The Philadelphia Eagles and Buffalo Bills dropped their first game of the season while the Detroit Lions have won four straight matchups.

New Orleans Saints quarterback Spencer Rattler speaks with the media from the Ochsner Sports Performance Center on Wednesday, October 8, 2025 ahead of Week 6 vs. the New England Patriots.

Drake Maye led the Patriots on a 37-yard drive to set up rookie Andy Borregales’ 52-yard field goal with 15 seconds left, and New England beat the Buffalo Bills 23-20, leaving the NFL without an undefeated team five weeks into the season.

The Patriots lead the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings. Buffalo is a 7.5-point favorite in the latest Patriots vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 49.