Analyzing Friday’s Houston vs. Duke odds and lines, with college basketball expert picks, predictions and best bets.

Howie Hoops predicts the two favorites, Duke and Florida, will win and cover in their Final Four matchups and advance to the national title game.

The Houston Cougars have been to this stage before in recent history. Four years ago, in fact. That team, led by Marcus Sasser and Quentin Grimes, rode a stifling defense to the Final Four, where the inconsistent offense finally came back to bite them in a loss to eventual champs Baylor.

The Houston Cougars dominated the Big 12 regular season and conference tournament. They had 22 wins and only one loss in all of conference play. They have also

Find out how Sammy P is wagering on the men's Final Four matchups and who he's eyeing in the Most Outstanding Player market.

What are Final Four odds now? What to know about Houston Cougars vs Duke Blue Devils point spread, moneyline, over/under for March Madness betting.

Madness wager between a pro gambler and an artificial-intelligence site will be decided by the winner of the Duke-Houston game in the Final Four.

The No. 1 Cougars beat the No. 2 Volunteers, 69-50, in the Elite Eight on Sunday after amassing a 34-15 halftime lead. Tennessee’s fourth basket of the game came on its 23rd shot attempt. And that shot by Jordan Gainey simply cut a 21-point lead into a 29-10 advantage for Houston with 3:37 to play before the break.

The four teams participating in the Final Four this weekend in San Antonio are a perfect microcosm of the new era in college basketball. While a team such as Duke has built its roster with former blue-chip recruits such as Cooper Flagg,