Nature

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

Discover the latest articles and news in related subjects. Besides the similar selectivity properties, GLIC also shares with its eukaryotic counterparts the sensitivity to blockers such as quaternary ...
Medical Xpress

Study provides structural insights into how cholesterol in the brain regulates ion channels and alters their function

Through a structural and functional approach, researchers from the Icahn School of Medicine at Mount Sinai and Stanford University Medical Center identified physical binding sites for cholesterol in ...
Nature

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Ethanol alters nerve signalling by interacting with proteins in the central nervous system, particularly pentameric ligand-gated ion channels. A recent series of mutagenesis experiments on Gloeobacter ...
Phys.org

Structural and dynamic differences between selective and non-selective ion channels

Most ion channels are very selective about the ions that may or may not pass through them. They may be conductive for potassium ions and non-conductive for sodium ions, or vice versa. However, a ...
EurekAlert!

New study provides structural insights into how cholesterol in the brain regulates ion channels and alters their function; findings could facilitate the development of ...

Senior Author: Paul A. Slesinger, PhD, Lillian and Henry M. Stratton Professor of Neuroscience and Director of the Center for Neurotechnology and Behavior, Icahn School of Medicine at Mount Sinai, New ...