A new article in the peer-reviewed journal Nucleic Acid Therapeutics describes the characterization of antibodies targeting antisense oligonucleotide (ASO) phosphorothioate and 2'-methoxyehtyl ...
Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...
The process of GLUT4 trafficking is central to the metabolic regulation of blood glucose levels. In both muscle and adipose cells, the insulin hormone triggers the mobilisation of intracellular ...
Anti-sense oligonucleotides (ASOs) are short, modified, single-stranded oligonucleotides—made from DNA or locked nucleic acid (LNA)—with enhanced stability, activity, and bioavailability. They ...
This study revealed two independent retrograde pathways: a sorting nexin–mediated pathway (orange) and a core retromer–mediated pathway (blue). In yeast, sorting nexins and the core retromer form a ...
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