In 1979, Alexander Rich, PhD, and his colleagues solved the structure of a self-complementary DNA hexamer and discovered that the molecule formed a left-handed double helix (Z-DNA). (Credit: Journal ...

MOF materials efficiently enrich circulating nucleic acids (cfDNA and cfRNA) in blood through a simple operational process, enabling various downstream nucleic acid detection techniques including PCR, ...

Conventional biologics are static; their structure and mechanism are fixed once they are developed. In contrast, nucleic acid therapies are inherently programmable—putting treatments once thought to ...

Since the discovery of the double-helical structure of DNA and postulation of the central dogma of molecular biology, stating that the flow of genetic information goes from DNA to RNA to protein, the ...