The new system, identified as De-scattering with Excitation Patterning (or DEEP), overcomes previous challenges with deep tissue microscopy and may revolutionize imaging methodology. Until now, ...

Scientists at MIT have developed a new microscopy technique that can make finer images of deeper tissue more quickly. The new technique offers the opportunity to obtain high-resolution images of blood ...

To create high-resolution, 3D images of tissues such as the brain, researchers often use two-photon microscopy, which involves aiming a high-intensity laser at the specimen to induce fluorescence ...

"Deep-UV ablation occurs only at the tissue surface and is therefore far less sensitive to beam focus variations," commented the project. "The shallow penetration of deep-UV radiation into the tissue ...

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues. However, traditional methods are often ...

Existing super-resolution techniques still face considerable challenges in complex deep tissue environments. For example, Stimulated Emission Depletion (STED) microscopy relies on a doughnut-shaped ...