Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Every time a cell divides, it must accurately copy its entire genetic instruction manual. Before this process can begin, cells load their DNA-copying motor—a complex of six subunits known as the ...

Further investigation suggested that this behavior was due to replication stress, an impaired ability of cells to copy their DNA in preparation for cell division. Further experiments showed that ...