Hosted on MSN

Scientists accidentally discover a pond organism that uses stop codons to build proteins instead of ending them — rewriting biology’s most universal rule

Somewhere in a sample of ordinary pond water, a single-celled organism has been quietly breaking one of biology’s most fundamental rules. Condylostoma magnum, a free-living ciliate barely visible to ...
Hosted on MSN

A pond organism found at Oxford University breaks biology’s most universal rule — its DNA uses stop codons to build proteins instead of ending them

In April 2021, Jamie McGowan was running a routine test. A computational biologist at the Earlham Institute in Norwich, England, McGowan had fed a single-celled organism’s genetic data into a ...
eLife

Profiling of terminating ribosomes reveals translational control at stop codons

Systematic characterization of terminating ribosomes uncovers sequence features influencing ribosome dynamics at stop codons with direct implications in 3' UTR translation.