Will Drake Maye and the Patriots hand the Bills their first loss in Stefon Diggs' return to Buffalo? Which running backs are primed for big outings? Our analysts provide bold predictions for Week 5 of the 2025 NFL season.

The month of October and Week 5 of the 2025 NFL season have arrived, and the San Francisco 49ers treated the football world to a stunning 26-23 overtime road win over the Los Angeles Rams despite a depleted depth chart.

Brad Evans looks at sportsbooks to make Week 5 fantasy football predictions, including more happy returns from breakout QB Drake Maye.

The Lions hit the road with a chance to extend their winning streak to four straight against a struggling Bengals team.

The Arizona Cardinals ' next game is Sunday afternoon against the Tennessee Titans. They will kick off from State Farm Stadium at 4:05 p.m. ET (1:05 p.m. Arizona time). The Titans have lost their first four games and have the worst offense in the league — yes, even worse than the Cardinals'.

Ravens have ruled out QB Lamar Jackson and five other players for the Week 5 matchup against the Houston Texans